Komfrey atau symphytum officinale l. adalah

The study indicated that oral treatment of rats with 10% Comfrey alcoholic extract reduced cell proliferation in this model. Scores of fibrosis, glycogen stores and the number of nucleolus organizing regions were not altered. On the other hand, the percentage of cells presenting megalocytosis (P = 0.0001) and vacuolar degeneration (P = 0.0001) was increased. for in vitro biological control of the phytopathogen Sclerotinia sclerotiorum (Lib.) Seleo de fungos endofticos de confrei (Symphytum officinale L.).

Comfrey treatment reduced the number of pre-neoplastic macroscopic lesions up to 1 mm (P в‰¤ 0.05), the percentage of oval cells (P = 0.0001) and mitotic figures (P = 0.007), as well as the number of Proliferating Cell Nuclear Antigen (PCNA) positive cells (P = 0.0001) and acidophilic pre-neoplastic nodules (P = 0.05). Non-parametric statistical tests (Mann-Whitney and П‡(2)) were used, and the level of significance was set at P в‰¤ 0.05. The term comfrey has been applied to several species in the genus Symphytum (Boraginaceae), and this is used most often for Symphytum officinale L. Macroscopic/microscopic quantitative analysis of PNL was performed. Wistar rats were sequentially treated with N-nitrosodiethylamine (ip) and 2-acetilaminofluorene (po), and submitted to hepatectomy to induce carcinogenesis promotion. Herein, the effects of chronic oral treatment of rats with 10% Comfrey ethanolic extract were evaluated in a RHM. In these studies, it is possible to observe easily the phenomena related to the early phases of tumor development, since pre-neoplastic lesions (PNLs) rise in about 1-2 months of chemical induction. However, the literature on this topic is very poor considering the studies performed under short-term carcinogenesis protocols, such as the 'resistant hepatocyte model' (RHM). Since the 1980s, its effects have been studied in long-term carcinogenesis studies, in which Comfrey extract is administered at high doses during several months and the neoplastic hepatic lesions are evaluated.

Comfrey or Symphytum officinale (L.) (Boraginaceae) is a very popular plant used for therapeutic purposes.

Komfrey atau symphytum officinale l. adalah